From Landmark Trials to the Front Lines of Thrombosis Prevention and Treatment for VTE and NVAF: A Real World Roadmap for Clinical Success with Direct Oral Anticoagulants—Practical Issues for Optimizing Efficacy and Safety of Factor Xa and DT Inhibitors for Stroke Prevention in AF and VTE Treatment—Drug Levels, Reversal Agents, Lifestyle Modification, Cost-Effectiveness - Samuel Z. Goldhaber, MD – Program Co-Chairman