Immunotherapy in Advanced and Metastatic Cutaneous Squamous Cell Carcinoma (CSCC)

Expanding the Immunotherapeutic Toolkit for Late Stage Skin Cancer

Focus on the Rationale and Evidence-Based Role for PD-1 Targeted Immune Checkpoint Inhibition-Defining Unmet Needs in a Challenging Patient Population

Optimizing Survival and Clinical Outcomes in Metastatic CSCC

What Do Landmark Trials Teach Us About the Efficacy and Safety of PD-1 Targeting Immunotherapy in CSCC? Which Patients? When? For How Long? With What Results? -From Trial-Based Data to the Front Lines of Clinical Care in Patients with Advanced Skin Cancer

Interactive (ARS) Case Management and Dialogue Sessions Focused on Patient Case Management

Navigating the Immunotherapy Clinical Decision Tree in CSCC-Identifying Appropriate Candidates for PD-1 Checkpoint Inhibitor and Practical- Timing and Patient Selection- Aspects of Deploying Immunotherapy

Immunotherapy in Advanced and Metastatic Cutaneous Squamous Cell Carcinoma (CSCC)


Program Medium

Internet-based program


Estimated Time to Complete Educational Activity

1.5 hours


Course Overview

In this web-based program, physicians will learn how recent developments in multimodal therapies have advanced the management of advanced and metastatic cutaneous squamous cell carcinoma (CSCC)


Release Date

December 1, 2018


Expiration Date

December 1, 2020


Method of Physician Participation Utilized in Learning Process

There are no fees for participating and receiving CME credit for this activity. During the period December 1, 2018 to December 1, 2020 participants must:
1) read the learning objectives and faculty disclosures;
2) study the educational activity, and are expected to view all 6 segments totaling 1.5 hours to successfully complete the activity and earn CME credit;
3) register and complete the evaluation form and post-test;
4) score 100% on the post-test; and
5) print out your CME certificate.



Participation in this WebCAST is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.


Grantor Support

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi Genzyme


Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Postgraduate Institute for Medicine and CMEducation Resources, LLC. Postgraduate Institute for Medicine  is accredited by the ACCME to provide continuing medical education for physician.


Credit Designation Statement

Postgraduate Institute for Medicine  designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Policy on Faculty & Provider Disclosure

Postgraduate Institute for Medicine  requires instructors, planners, managers and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to Postgraduate Institute for Medicine  policy.  The existence or absence of COI for everyone in a position to control content will be disclosed to participants prior to the start of each activity.


Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credits™ from organizations accredited by the ACCME.

American Academy of Nurse Practitioners (AANP) accepts AMA PRA Category 1 Credits™ from organizations accredited by the ACCME.

American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credits™ from organizations accredited by the ACCM.


Program Faculty and Disclosure


Associate Professor of Medicine
Division of Medical Oncology
Director, Cutaneous Oncology Program
University of Colorado School of Medicine


Consultant: Genentech

Research Support: Genentech, Novartis


Sherrif F. Ibrahim, M.D., Ph.D.

Associate Professor, Dermatology

Division of Dermatologic Surgery

Wilmot Cancer Center

University of Rochester
Rochester, NY


Consultant: Regeneron

Non-CME/CE Speaker: Genentech, Sciton

Contracted Research: Regeneron, Castle Biosciences 



Educational Objectives

Upon completion of this activity, participants will be able to:

  • Assess current NCCN and ASCO and AAD standards for diagnosing, staging, and treating advanced or metastatic CSCC
  • Better understand the epidemiology, risk factors, and disease burden of advanced CSCC and the unmet need for better therapies to improve outcomes in the challenging population with advanced local spread and metastases
  • Better understand the design, rationale, PFS, response rates, efficacy and side effects of PD-1 checkpoint inhibitors in the setting of CSCC and identify patients who can benefit from this form of immunotherapy
  • Discuss the existing gaps in therapy for patients with advanced CSCC, and the mechanistic and pathoimmunobiological rationale for considering immune system-targeting therapies, including PD-1 checkpoint inhibitors, for deployment in patients who have failed or progressing on chemotherapy
  • Discuss and characterize the local stromal and immune-based microenvironment in CSCC and how immune-directed strategies may act to improve anti-tumor effects by maintaining and activating infiltrating and circulating T-cells


Hardware and Software Requirements:

To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.


Privacy Policy

When you participate in a CME activity offered by CMEducation Resources, we ask you for your name, degree, affiliation, street address, telephone number, fax number, and/or e-mail address (the "Information"). We use that Information in the following ways:

• We use the Information to grade your post-test and to send you a certificate of completion of the CME activity. If we use a third-party company to grade your post-test and issue certificates of completion, we will give the Information to that company for that purpose only.

• For each CME activity that you take, you must complete an evaluation questionnaire. That questionnaire asks if you are willing to participate in a follow-up survey. If you answer yes, we will use your name and contact information to send you the survey.

• We may use the Information to send you information about other CME activities that CMEducation Resources is offering.

• If our company is acquired by or merged into another company, we may make the Information available to the new owner/entity to use in the ways described above, to enable it to continue our business.

• You should check this privacy policy periodically to see whether we have made any changes