New Frontiers and Technological Advances in Noninvasive Prenatal Screening


The Changing Paradigm for Prenatal Screening for Fetal Aneuploidy:

Technologies Used in Counting versus SNP-based NIPS, Overall Performance of NIPS, Sensitivity Specificity and PPV Microdeletion Detection, and Microdeletions Performance for SNP-based NIPS


The Role of SNP-Based Diagnostic Tests for Detecting the Full Range of Fetal Abnormalities

Including Critical Microdeletions and Aneuplodies: What Do the Clinical Studies Teach Us? How Do They Guide Us at the Front Lines of OB-GYN and MFM Care? Peter Benn, PhD – Program Chair




Program Medium

Internet-based program

 

Estimated Time to Complete Educational Activity

1.5 hours

 

Course Overview

In this web-based program, physicians will learn how ecent developments in noninvasive prenatal screening have helped to advance the detection of fetal genetic abnormalities.

 

Release Date

June 6, 2017

 

Expiration Date

June 6, 2019

 

Method of Physician Participation Utilized in Learning Process

There are no fees for participating and receiving CME credit for this activity. During the period June 6, 2017 through June 6, 2019 participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view all 7 segments totaling 2.5 hours to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out your CME certificate.

 

Registration

Participation in this WebCAST is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals..

 

Grantor Support

Supported by an educational grant from Natera.

 

Accreditation Statement

This activity has been planned and implemented in accordance with accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Massachusetts Medical School and CMEducation Resources, LLC. University of Massachusetts Medical School  is accredited by the ACCME to provide continuing medical education for physicians.

 

Credit Designation Statement

The University of Massachusetts Medical School designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

 

Policy on Faculty & Provider Disclosure

It is the policy of the University of Massachusetts Medical School to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.

 

Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credits™ from organizations accredited by the ACCME.
American Academy of Nurse Practitioners (AANP) accepts AMA PRA Category 1 Credits™ from organizations accredited by the ACCME.
American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credits™ from organizations accredited by the ACCM.

 

Program Faculty and Disclosure

PETER BENN, PhD
Program Chair
Professor Emeritus
Department of Genetics and Genome Sciences
Director, Human Genetics Laboratory
University of Connecticut Health Center
Farmington, CT
 
Consultant: Natera
Stock Options: Natera

 
ERROL R. NORWITZ, MD, PhD, MBA
Louis E. Phaneuf Professor, Departments of Obstetrics & Gynecology
Tufts University School of Medicine
Chairman, Department of Obstetrics & Gynecology
Tufts Medical Center
Boston, MA


Consultant: Natera
 
 
MIKE RUMA, MD, MPH, FACOG
Perinatal Associates of New Mexico
Albuquerque, NM
 
Consultant: Natera
 

Educational Objectives

Upon completion of this activity, participants will be able to:

  • Outline the evolution of prenatal diagnosis and screening for chromosome abnormalities such as Down syndrome;
  • Apply non-invasive prenatal screening (NIPT) using cell-free fetal DNA, and understand how it integrates into the current paradigms for screening and diagnostic testing for aneuploidy;
  • Compare the different laboratory techniques used to amplify cell-free DNA; and how the two methods, generally described as the “counting method” and the “SNP (single nucleotide polymorphism)based testing” differ in their clinical application, limitations, and potential advantages;
  • Detail the SNP based approach to NIPT, and outline the advantages this technology offers compared to the “counting method”; and, specifically, how the different methodologies—i.e. the counting method versus that focused on SNP technology—impact the reliability, predictive value, and usefulness of the NIPT results;
  • Apply current practice guidelines from various professional societies such as ACOG and SMFM regarding the integration of NIPT into clinical practice; including, a clinical roadmap for how, on a practical level, clinicians should utilize NIPT in their practice

 

Hardware and Software Requirements:

To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.

 

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  • We use the Information to grade your post-test and to send you a certificate of completion of the CME activity. If we use a third-party company to grade your post-test and issue certificates of completion, we will give the Information to that company for that purpose only.
  • For each CME activity that you take, you must complete an evaluation questionnaire. That questionnaire asks if you are willing to participate in a follow-up survey. If you answer yes, we will use your name and contact information to send you the survey.
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Disclaimer

Copyright © 2017 by CMEducation Resources, LLC All rights reserved. 

Reproduction, distribution, or translation without express written permission is strictly prohibited. 

Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity. 

Content on this webcast is not meant to be, nor substitute for national guidelines or recommendations generated by professional, academic societies, colleges, or associations. 

Content on this webcast is intended for educational value only. Its contents, analyses, and any recommendation made herein are intended to make scientific information and opinion available to health professionals, to stimulate thought, and further investigation. This webcast is not designed nor is any aspect of the contents here intended to provide advice regarding medical diagnosis or treatment for any individual case. Any decisions regarding diagnosis and/or management of any individual patient or group of patients should be made on individual basis after having consulted appropriate sources, whether they be appropriate consultants and/or guidelines and recommendations issued by national organizations, professional societies, governmental health organizations, or similar bodies. This webcast is not intended for use by the layman. 

Opinions expressed herein are not necessarily those of CMEducation Resources, LLC, program supporters or accreditors, but reflect the opinions and analyses of the experts who have authored the material. Mention of products or services does not constitute endorsement. Clinical, legal, financial, and other comments are offered for general guidance only; and professional counsel should be sought for all specific situations.